HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: H4 (P62805)
Histone H4
Gene: H4C1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	30804502, 25494638, 31248990
Identification Methods	affinity chromatography technology, enzymatic study, proximity labelling technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	CENP-T_C~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1365 Hs			1 103
+	Hs
		917879 NSD3_HUMAN (116-1340): 0: 758: 45.19		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917338 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356466 SET1_YEAST (995-1203): 4.99e-62: 233: 31.11		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Hs
		917944 EHMT1_HUMAN (906-1224): 5.39e-55: 212: 21.43		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917760 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917878 SETD2_HUMAN (852-1238): 1.1e-53: 209: 27.74		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356561 SET2_YEAST (972-1208): 9.39e-61: 225: 35.12		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Hs
		917145 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		918135 KMT2B_HUMAN (1049-1203): 1.21e-41: 170: 32.05		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917762 NSD1_HUMAN (69-658): 1.83e-25: 117: 14.33		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		152623 KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54		H4_HUMAN (1-103): 1.38e-48: 151: 100.00