HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36089195
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AWS~Histone, Histone~PWWP, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1365 Hs			1 136
+	Hs
		331780 NSD2_HUMAN (1-1365): 0: 980: 100.00		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		331823 NSD2_HUMAN (1-1365): 0: 980: 100.00		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		331833 NSD2_HUMAN (1-1365): 0: 980: 100.00		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		331748 NSD2_HUMAN (1-1365): 0: 980: 100.00		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		935205 NSD3_HUMAN (116-1340): 0: 758: 45.19		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952607 NSD3_HUMAN (116-1340): 0: 758: 45.19		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		1086307 NSD3_HUMAN (116-1340): 0: 758: 45.19		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		1157224 NSD3_HUMAN (116-1340): 0: 758: 45.19		H3C_HUMAN (1-136): 1.99e-56: 173: 95.59
+	Hs
		828367 NSD3_HUMAN (116-1340): 0: 758: 45.19		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		203659 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		203664 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		935237 SUV92_HUMAN (826-1203): 4.69e-72: 249: 20.84		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		203722 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Dm
		356118 ASH1_DROME (991-1237): 8.56e-67: 251: 37.65		H3_DROME (1-136): 5.32e-59: 180: 97.06
+	Hs
		952627 SUV92_HUMAN (826-1203): 4.69e-72: 249: 20.84		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		203706 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		H37_HUMAN (1-136): 4.54e-57: 175: 94.12
+	Hs
		203711 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		H3C_HUMAN (1-136): 1.99e-56: 173: 95.59
+	Hs
		935276 ASH1L_HUMAN (924-1232): 1.1e-57: 222: 31.75		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Sc
		755791 SET1_YEAST (995-1203): 4.99e-62: 233: 31.11		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Sc
		810349 SET2_YEAST (972-1208): 9.39e-61: 225: 35.12		H3_YEAST (1-136): 3.62e-54: 168: 90.44