HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: NUMA1 (Q14980)
Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)
Gene: NUMA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	31248990, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1365 Hs			1 2115
+	Hs
		331816 NSD2_HUMAN (1-1365): 0: 980: 100.00		PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37
+	Hs
		331711 NSD2_HUMAN (1-1365): 0: 980: 100.00		TPR_HUMAN (2-620): 2.42e-18: 94.7: 12.04
+	Hs
		203688 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		1061250 SUV92_HUMAN (826-1203): 4.69e-72: 249: 20.84		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		1061121 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		1061253 EHMT1_HUMAN (906-1224): 5.39e-55: 212: 21.43		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		975254 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Mm
		1149802 Q6AXH7_MOUSE (904-1188): 1.25e-58: 218: 22.48		PLEC_MOUSE (21-1207): 2.95e-35: 150: 12.47
+	Hs
		724847 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62
+	Hs
		1068676 ASH1L_HUMAN (924-1232): 1.1e-57: 222: 31.75		PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37
+	Hs
		725169 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34
+	Hs
		1068540 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37
+	Hs
		1034582 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		GOGA4_HUMAN (5-528): 2.18e-12: 75: 11.24
+	Hs
		828622 SETD2_HUMAN (852-1238): 1.1e-53: 209: 27.74		CENPF_HUMAN (1458-2037): 1.6e-10: 69.3: 9.97