HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: H2A2C (Q16777)
Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q)
Gene: H2AC20

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	AWS~Histone, AWS~Histone_H2A_C, Histone~PWWP, Histone~SET
Common GO terms	GO:0005634 - nucleus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1365 Hs			1 129
+	Hs
		331703 NSD2_HUMAN (1-1365): 0: 980: 100.00		H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06
+	Hs
		331860 NSD2_HUMAN (1-1365): 0: 980: 100.00		H2A1C_HUMAN (1-127): 4.25e-65: 195: 96.06
+	Hs
		203696 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00
+	Hs
		203730 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83
+	Hs
		1080241 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		H2A1H_HUMAN (1-127): 1.77e-65: 196: 96.06
+	Hs
		470396 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06
+	Hs
		391719 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49
+	Hs
		470560 EHMT1_HUMAN (906-1224): 5.39e-55: 212: 21.43		H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06
+	Hs
		470506 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06
+	Hs
		555602 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12
+	Sc
		392487 SET2_YEAST (972-1208): 9.39e-61: 225: 35.12		H2A2_YEAST (16-129): 1.63e-52: 163: 78.95
+	Dm
		785621 EZ_DROME (1011-1188): 2.7e-54: 206: 31.02		H2A_DROME (17-122): 5.55e-57: 174: 92.45
+	Hs
		470359 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06
+	Hs
		391662 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49
+	Hs
		152575 KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54		H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49
+	Dm
		332757 CHDM_DROME (1238-1285): 6.78e-12: 72.7: 42.00		H2A_DROME (17-122): 5.55e-57: 174: 92.45