HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: ZCCHV (Q7Z2W4)
Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP)
Gene: ZC3HAV1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0046872 - metal ion binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1365 Hs			1 902
+	Hs
		331836 NSD2_HUMAN (1-1365): 0: 980: 100.00		PARPT_HUMAN (273-895): 0: 578: 23.82
+	Hs
		1080071 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		ZCCHV_HUMAN (1-902): 0: 1277: 100.00
+	Hs
		331702 NSD2_HUMAN (1-1365): 0: 980: 100.00		PARP1_HUMAN (359-885): 5.92e-142: 449: 13.20
+	Hs
		1188822 NSD3_HUMAN (116-1340): 0: 758: 45.19		PARPT_HUMAN (273-895): 0: 578: 23.82
+	Hs
		455840 NSD3_HUMAN (116-1340): 0: 758: 45.19		PARP1_HUMAN (359-885): 5.92e-142: 449: 13.20
+	Hs
		1188881 EHMT1_HUMAN (906-1224): 5.39e-55: 212: 21.43		PARPT_HUMAN (273-895): 0: 578: 23.82
+	Hs
		1188725 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		PARPT_HUMAN (273-895): 0: 578: 23.82
+	Hs
		1188821 SETD2_HUMAN (852-1238): 1.1e-53: 209: 27.74		PARPT_HUMAN (273-895): 0: 578: 23.82
+	Hs
		975280 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		PARPT_HUMAN (273-895): 0: 578: 23.82
+	Hs
		1188726 NSD1_HUMAN (69-658): 1.83e-25: 117: 14.33		PARPT_HUMAN (273-895): 0: 578: 23.82
+	Hs
		455486 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		PARP1_HUMAN (359-885): 5.92e-142: 449: 13.20
+	Hs
		455884 EHMT1_HUMAN (906-1224): 5.39e-55: 212: 21.43		PARP1_HUMAN (359-885): 5.92e-142: 449: 13.20
+	Hs
		152662 KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54		PARPT_HUMAN (273-895): 0: 578: 23.82
+	Hs
		455763 NSD1_HUMAN (69-658): 1.83e-25: 117: 14.33		PARP1_HUMAN (359-885): 5.92e-142: 449: 13.20
+	Hs
		203805 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		PARP2_HUMAN (382-885): 1.99e-66: 235: 12.59