HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	18156491, 18172012
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1365 Hs			1 488
+	Mm
		140296 NSD2_MOUSE (1-1365): 0: 989: 90.92		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		331809 NSD2_HUMAN (1-1365): 0: 980: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		203750 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		222461 SUV91_MOUSE (830-1202): 5.62e-72: 249: 20.69		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		1080187 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		936404 Q6AXH7_MOUSE (904-1188): 1.25e-58: 218: 22.48		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		1270450 EHMT1_HUMAN (906-1224): 5.39e-55: 212: 21.43		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1270381 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1038522 KMT2E_HUMAN (826-1229): 6.15e-67: 252: 16.95		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		140205 SUV91_MOUSE (830-1202): 5.62e-72: 249: 20.69		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		203679 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		140274 EZH2_MOUSE (904-1188): 7.38e-59: 219: 22.48		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		1038412 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Dm
		785632 EZ_DROME (1011-1188): 2.7e-54: 206: 31.02		HDAC1_DROME (5-472): 0: 653: 77.92
+	Hs
		1038721 EHMT1_HUMAN (906-1224): 5.39e-55: 212: 21.43		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038631 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177134 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Mm
		222457 SUV91_MOUSE (830-1202): 5.62e-72: 249: 20.69		HDAC3_MOUSE (10-431): 0: 574: 58.49
+	Hs
		177306 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Sc
		755785 SET1_YEAST (995-1203): 4.99e-62: 233: 31.11		HOS2_YEAST (11-430): 5.02e-174: 498: 47.18