HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: H2A1C (Q93077)
Histone H2A type 1-C (H2A-clustered histone 6) (Histone H2A/l)
Gene: H2AC6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AWS~Histone, AWS~Histone_H2A_C, Histone~PWWP, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1365 Hs			1 130
+	Hs
		331703 NSD2_HUMAN (1-1365): 0: 980: 100.00		H2A1_HUMAN (1-130): 1.29e-67: 201: 98.46
+	Hs
		331824 NSD2_HUMAN (1-1365): 0: 980: 100.00		H2A2C_HUMAN (1-130): 5.75e-65: 194: 96.92
+	Hs
		203730 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		H2A2B_HUMAN (1-130): 3.14e-66: 198: 95.39
+	Hs
		203696 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		H2A2C_HUMAN (1-130): 5.75e-65: 194: 96.92
+	Hs
		391719 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		H2A1B_HUMAN (1-130): 1.52e-67: 201: 98.46
+	Hs
		470396 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		H2A1_HUMAN (1-130): 1.29e-67: 201: 98.46
+	Hs
		1080241 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		H2A1H_HUMAN (1-128): 7.48e-67: 199: 98.44
+	Hs
		470560 EHMT1_HUMAN (906-1224): 5.39e-55: 212: 21.43		H2A1_HUMAN (1-130): 1.29e-67: 201: 98.46
+	Hs
		470506 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		H2A1_HUMAN (1-130): 1.29e-67: 201: 98.46
+	Sc
		392487 SET2_YEAST (972-1208): 9.39e-61: 225: 35.12		H2A2_YEAST (16-128): 3.45e-59: 180: 81.42
+	Hs
		555602 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		H2AX_HUMAN (1-130): 1.1e-63: 192: 89.55
+	Dm
		785621 EZ_DROME (1011-1188): 2.7e-54: 206: 31.02		H2A_DROME (17-125): 1.09e-59: 181: 90.83
+	Hs
		391662 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		H2A1B_HUMAN (1-130): 1.52e-67: 201: 98.46
+	Hs
		470359 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		H2A1_HUMAN (1-130): 1.29e-67: 201: 98.46
+	Hs
		152575 KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54		H2A1B_HUMAN (1-130): 1.52e-67: 201: 98.46
+	Dm
		332757 CHDM_DROME (1238-1285): 6.78e-12: 72.7: 42.00		H2A_DROME (17-125): 1.09e-59: 181: 90.83