HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: DTL (Q9NZJ0)
Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)
Gene: DTL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26771714
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1365 Hs			1 730
+	Hs
		331862 NSD2_HUMAN (1-1365): 0: 980: 100.00		SNR40_HUMAN (258-581): 7.14e-39: 149: 13.90
+	Hs
		1288292 NSD3_HUMAN (116-1340): 0: 758: 45.19		SNR40_HUMAN (258-581): 7.14e-39: 149: 13.90
+	Hs
		1080207 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		FBXW7_HUMAN (175-521): 4.51e-54: 200: 12.16
+	Hs
		1281314 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		FBXW7_HUMAN (175-521): 4.51e-54: 200: 12.16
+	Hs
		203735 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		DAW1_HUMAN (231-583): 3.15e-41: 157: 12.18
+	Hs
		903444 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		WDR5_HUMAN (11-243): 2.2e-54: 192: 13.95
+	At
		1319861 ATX1_ARATH (721-1213): 1.34e-72: 266: 17.23		WDR5A_ARATH (8-168): 7.72e-34: 134: 16.19
+	Hs
		975303 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		FBXW7_HUMAN (175-521): 4.51e-54: 200: 12.16
+	Hs
		903149 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		WDR5_HUMAN (11-243): 2.2e-54: 192: 13.95
+	Hs
		903604 KMT2B_HUMAN (1049-1203): 1.21e-41: 170: 32.05		WDR5_HUMAN (11-243): 2.2e-54: 192: 13.95
+	Hs
		1288291 SETD2_HUMAN (852-1238): 1.1e-53: 209: 27.74		SNR40_HUMAN (258-581): 7.14e-39: 149: 13.90
+	Hs
		1224155 KMT2E_HUMAN (826-1229): 6.15e-67: 252: 16.95		WDR12_HUMAN (227-403): 1.54e-14: 78.4: 20.00
+	Hs
		975304 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		SNR40_HUMAN (258-581): 7.14e-39: 149: 13.90
+	Hs
		1288387 KMT2B_HUMAN (1049-1203): 1.21e-41: 170: 32.05		SNR40_HUMAN (258-581): 7.14e-39: 149: 13.90
+	Zm
		35725 A0A1D6M742_MAIZE (870-1202): 1.84e-59: 220: 17.95		A0A1D6LQJ4_MAIZE (346-585): 7.19e-14: 75.1: 11.24
+	Hs
		1317584 SETD2_HUMAN (852-1238): 1.1e-53: 209: 27.74		NLE1_HUMAN (343-590): 4e-15: 80.5: 10.97
+	Hs
		152678 KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54		FBXW7_HUMAN (175-521): 4.51e-54: 200: 12.16
+	Hs
		152663 KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54		WDR5B_HUMAN (190-502): 2.83e-55: 194: 16.51
+	Hs
		152622 KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54		WDR5_HUMAN (11-243): 2.2e-54: 192: 13.95