HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: BAZ2A (Q9UIF9)
Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3)
Gene: BAZ2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31248990
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Bromodomain~PHD, PHD~PHD
Common GO terms	GO:0005634 - nucleus GO:0005730 - nucleolus GO:0006355 - regulation of DNA-templated transcription GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1365 Hs			1 1905
+	Hs
		331900 NSD2_HUMAN (1-1365): 0: 980: 100.00		BAZ1B_HUMAN (500-1900): 3.26e-54: 211: 12.28
+	Hs
		1017344 NSD3_HUMAN (116-1340): 0: 758: 45.19		BPTF_HUMAN (1676-1766): 1.74e-09: 65.7: 28.57
+	Hs
		1080260 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		RSF1_HUMAN (1259-1755): 6.03e-54: 210: 15.67
+	Hs
		164474 SETD2_HUMAN (852-1238): 1.1e-53: 209: 27.74		TRI66_HUMAN (1155-1902): 2.64e-55: 215: 17.39
+	Mm
		102330 EZH2_MOUSE (904-1188): 7.38e-59: 219: 22.48		G3UWZ0_MOUSE (524-1891): 3.78e-49: 195: 14.09
+	Hs
		1080383 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		BAZ1A_HUMAN (524-1891): 2.93e-45: 182: 13.90
+	Hs
		1080191 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		KAT2B_HUMAN (1772-1896): 2.08e-44: 177: 37.30
+	Hs
		1080481 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		TRI33_HUMAN (1074-1901): 1.17e-42: 173: 13.92
+	Hs
		1051290 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		DCTN1_HUMAN (392-1518): 5.64e-41: 168: 10.18
+	Hs
		998760 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		EP300_HUMAN (1150-1900): 7.93e-41: 168: 12.63
+	Hs
		1271486 EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65		KAT2B_HUMAN (1772-1896): 2.08e-44: 177: 37.30
+	Hs
		1080295 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		CECR2_HUMAN (1759-1904): 3.8e-40: 165: 28.77
+	Hs
		1018505 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		CHD3_HUMAN (1541-1904): 7.58e-39: 162: 13.67
+	Sc
		810355 SET2_YEAST (972-1208): 9.39e-61: 225: 35.12		GCN5_YEAST (1767-1898): 1.4e-39: 156: 33.33
+	Hs
		1315219 SETD2_HUMAN (852-1238): 1.1e-53: 209: 27.74		CECR2_HUMAN (1759-1904): 3.8e-40: 165: 28.77
+	Hs
		975235 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		CHD3_HUMAN (1541-1904): 7.58e-39: 162: 13.67
+	Hs
		1080411 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		ITSN2_HUMAN (195-834): 2.37e-14: 81.5: 11.43
+	Hs
		1017304 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		BPTF_HUMAN (1676-1766): 1.74e-09: 65.7: 28.57
+	Hs
		975298 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		CBP_HUMAN (86-477): 8.54e-09: 63.4: 9.52
+	Hs
		152675 KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54		CBP_HUMAN (86-477): 8.54e-09: 63.4: 9.52