HitPredict

Interactor 1: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Interactor 2: TPX2 (Q9ULW0)
Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100)
Gene: TPX2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31248990
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1365 Hs			1 747
+	Hs
		203809 SUV91_HUMAN (830-1202): 5.28e-73: 251: 20.52		TPX2_HUMAN (1-747): 2.4e-154: 468: 100.00
+	Hs
		1080472 EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48		TPX2_HUMAN (1-747): 2.4e-154: 468: 100.00
+	Hs
		1271116 EZH1_HUMAN (932-1188): 1.16e-57: 216: 24.07		TPX2_HUMAN (1-747): 2.4e-154: 468: 100.00
+	Zm
		8429 A0A1D6ISR3_MAIZE (1059-1203): 2.06e-56: 216: 34.48		A0A1D6ENV3_MAIZE (661-741): 6.91e-10: 61.4: 24.39
+	Hs
		975294 KMT2A_HUMAN (1049-1203): 7.37e-42: 171: 32.05		TITIN_HUMAN (55-725): 1e-09: 64.5: 11.90
+	Dm
		332876 CHDM_DROME (1238-1285): 6.78e-12: 72.7: 42.00		Q9VPR2_DROME (169-658): 4.83e-09: 61.8: 11.49