HitPredict

Interactor 1: O96689 (O96689)
FI11703p (Rad21 mitotic cohesin) (Verthandi, isoform A)
Gene: vtd

Interactor 2: Q9VXE9 (Q9VXE9)
Structural maintenance of chromosomes protein
Gene: SMC3

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	15375666, 25189620, 27996020, 12573216
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Rad21_Rec8~SMC_N, Rad21_Rec8_N~SMC_N
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0007064 - mitotic sister chromatid cohesion GO:0008278 - cohesin complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 715 Dm			1 1200
+	Dm
		332177 O96689_DROME (1-715): 0: 909: 100.00		Q9VCD8_DROME (2-1184): 4.47e-72: 265: 15.44
+	Mm
		1142822 RAD21_MOUSE (1-710): 3.4e-152: 457: 34.69		SMC3_MOUSE (1-1200): 2.67e-98: 342: 52.87
+	Xl
		1150103 Q6DCL7_XENLA (1-497): 1.59e-144: 438: 41.62		Q8AW91_XENLA (1-1200): 6.72e-100: 347: 52.63
+	Xl
		292737 RAD21_XENLA (1-497): 2.01e-143: 435: 41.31		SMC3_XENLA (1-1200): 8.39e-101: 349: 52.89
+	Xl
		292746 RAD21_XENLA (1-497): 2.01e-143: 435: 41.31		Q8AW91_XENLA (1-1200): 6.72e-100: 347: 52.63
+	Hs
		224554 RAD21_HUMAN (1-517): 5.58e-145: 439: 38.69		SMC3_HUMAN (1-1200): 3.83e-98: 342: 52.96
+	Mm
		57599 RD21L_MOUSE (1-501): 4.67e-142: 429: 37.67		SMC3_MOUSE (1-1200): 2.67e-98: 342: 52.87
+	Mm
		1142821 RAD21_MOUSE (1-710): 3.4e-152: 457: 34.69		SMC1A_MOUSE (2-1194): 2.2e-78: 284: 16.88
+	Mm
		1207970 REC8_MOUSE (1-536): 4.13e-129: 397: 17.66		SMC3_MOUSE (1-1200): 2.67e-98: 342: 52.87
+	Hs
		224536 RAD21_HUMAN (1-517): 5.58e-145: 439: 38.69		SMC4_HUMAN (1-1189): 1.42e-81: 294: 15.76
+	Mm
		1142818 RAD21_MOUSE (1-710): 3.4e-152: 457: 34.69		SMC1B_MOUSE (2-1200): 2.58e-74: 272: 15.74
+	Hs
		224250 RAD21_HUMAN (1-517): 5.58e-145: 439: 38.69		SMC2_HUMAN (1-1200): 4.34e-78: 283: 20.20
+	Hs
		224434 RAD21_HUMAN (1-517): 5.58e-145: 439: 38.69		SMC1A_HUMAN (2-1194): 3.79e-78: 283: 16.88
+	Mm
		57598 RD21L_MOUSE (1-501): 4.67e-142: 429: 37.67		SMC1A_MOUSE (2-1194): 2.2e-78: 284: 16.88
+	Hs
		224479 RAD21_HUMAN (1-517): 5.58e-145: 439: 38.69		SMC1B_HUMAN (2-1200): 1.83e-71: 263: 15.81
+	Xl
		292726 RAD21_XENLA (1-497): 2.01e-143: 435: 41.31		SMC1A_XENLA (2-1194): 8.67e-73: 267: 17.20
+	Mm
		57597 RD21L_MOUSE (1-501): 4.67e-142: 429: 37.67		SMC1B_MOUSE (2-1200): 2.58e-74: 272: 15.74
+	Mm
		1207969 REC8_MOUSE (1-536): 4.13e-129: 397: 17.66		SMC1B_MOUSE (2-1200): 2.58e-74: 272: 15.74
+	Sp
		193873 RAD21_SCHPO (1-518): 1.54e-118: 370: 23.12		SMC3_SCHPO (1-1195): 1.53e-83: 299: 36.24
+	Sp
		293280 RAD21_SCHPO (1-518): 1.54e-118: 370: 23.12		SMC1_SCHPO (2-1187): 5.07e-71: 261: 15.14