HitPredict

Interactor 1: O97102 (O97102)
Small ubiquitin-related modifier (SUMO)
Gene: Sumo

Interactor 2: Q7KUA4 (Q7KUA4)
SUMO-activating enzyme subunit
Gene: Uba2

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	11884525, 10995744
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Rad60-SLD~ThiF
Common GO terms	GO:0002225 - positive regulation of antimicrobial peptide production GO:0005634 - nucleus GO:0016925 - protein sumoylation GO:0045752 - positive regulation of Toll signaling pathway
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 90 Dm			1 700
+	Rn
		70077 SUMO3_RAT (1-88): 3.4e-37: 122: 69.57		B1WC32_RAT (4-665): 0: 608: 46.51
+	Hs
		879160 SUMO3_HUMAN (1-90): 5.77e-37: 121: 69.15		SAE2_HUMAN (4-665): 0: 590: 47.03
+	Hs
		902787 SUMO2_HUMAN (1-89): 1.32e-35: 117: 67.02		SAE2_HUMAN (4-665): 0: 590: 47.03
+	Hs
		102176 SUMO5_HUMAN (1-88): 3.68e-33: 111: 47.42		SAE2_HUMAN (4-665): 0: 590: 47.03
+	Hs
		928217 SUMO1_HUMAN (7-88): 2.32e-32: 109: 53.66		SAE2_HUMAN (4-665): 0: 590: 47.03
+	Sc
		854615 SMT3_YEAST (8-89): 2.96e-29: 101: 46.34		UBA2_YEAST (2-671): 0: 532: 30.59
+	Sp
		140839 PMT3_SCHPO (2-88): 4.99e-37: 122: 52.87		UBA2_SCHPO (11-620): 9.76e-170: 502: 34.12
+	Rn
		1137284 SUMO3_RAT (1-88): 3.4e-37: 122: 69.57		UBA1_RAT (8-151): 9.21e-29: 125: 25.69
+	Hs
		607044 SUMO2_HUMAN (1-89): 1.32e-35: 117: 67.02		UBA1_HUMAN (8-196): 8.92e-30: 128: 22.75