HitPredict

Interactor 1: PLK4 (O97143)
Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase SAK)
Gene: SAK

Interactor 2: Q9VDE3 (Q9VDE3)
LD08669p (Slimb) (Supernumerary limbs, isoform A) (Supernumerary limbs, isoform C)
Gene: slmb

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.748

Property	Details
Experiments	19084407, 19171756, 20852615, 24184097, 24184099, 25688134, 25646492, 30256714, 23000383
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0046599 - regulation of centriole replication
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 769 Dm			1 510
+	Ce
		1274779 ZYG1_CAEEL (2-737): 1.17e-144: 442: 21.14		SEL10_CAEEL (268-509): 3.52e-56: 198: 31.60
+	Hs
		129069 PLK4_HUMAN (8-287): 4.23e-122: 391: 57.86		FBW1A_HUMAN (322-510): 1e-49: 182: 30.69
+	Hs
		129064 PLK4_HUMAN (8-287): 4.23e-122: 391: 57.86		FBW1B_HUMAN (322-510): 2.18e-48: 176: 30.69
+	Hs
		861990 PLK1_HUMAN (19-266): 7.37e-56: 204: 41.04		FBW1A_HUMAN (322-510): 1e-49: 182: 30.69
+	Hs
		160864 AURKA_HUMAN (11-267): 2.54e-54: 194: 38.91		FBW1A_HUMAN (322-510): 1e-49: 182: 30.69
+	Hs
		861879 PLK1_HUMAN (19-266): 7.37e-56: 204: 41.04		FBXW7_HUMAN (358-510): 1.82e-37: 148: 28.57
+	Hs
		1281434 PLK2_HUMAN (19-269): 6.19e-55: 202: 38.58		FBXW7_HUMAN (358-510): 1.82e-37: 148: 28.57
+	Hs
		160697 AURKA_HUMAN (11-267): 2.54e-54: 194: 38.91		FBXW7_HUMAN (358-510): 1.82e-37: 148: 28.57
+	Hs
		1281310 AURKB_HUMAN (10-267): 4.08e-54: 192: 39.92		FBXW7_HUMAN (358-510): 1.82e-37: 148: 28.57