HitPredict

Interactor 1: LDHA (P00338)
L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59)
Gene: LDHA

Interactor 2: MK10 (P53779)
Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
Gene: MAPK10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.635

Property	Details
Experiments	25416956, 32296183, 31515488
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 332 Hs			1 464
+	Hs
		46514 LDHA_HUMAN (1-332): 7.2e-159: 449: 100.00		A0A286YFD7_HUMAN (39-464): 2.87e-170: 487: 98.12
+	Hs
		334135 LDHA_HUMAN (1-332): 7.2e-159: 449: 100.00		CDK2_HUMAN (61-365): 1.42e-136: 396: 34.41
+	Hs
		173802 LDHA_HUMAN (1-332): 7.2e-159: 449: 100.00		MK13_HUMAN (43-411): 3.49e-133: 390: 45.55
+	Hs
		334208 LDHA_HUMAN (1-332): 7.2e-159: 449: 100.00		Q499Y8_HUMAN (146-464): 3.23e-133: 388: 97.49
+	Hs
		421968 LDHB_HUMAN (1-331): 9.03e-153: 433: 75.30		CDK2_HUMAN (61-365): 1.42e-136: 396: 34.41
+	Hs
		173811 LDHB_HUMAN (1-331): 9.03e-153: 433: 75.30		MK13_HUMAN (43-411): 3.49e-133: 390: 45.55
+	Hs
		625192 MDHM_HUMAN (1-332): 1.4e-108: 321: 19.19		CDK2_HUMAN (61-365): 1.42e-136: 396: 34.41
+	Hs
		173855 MDHM_HUMAN (1-332): 1.4e-108: 321: 19.19		MK13_HUMAN (43-411): 3.49e-133: 390: 45.55
+	Rn
		387835 LDHA_RAT (1-332): 9.9e-157: 443: 94.28		MK03_RAT (58-397): 3.58e-85: 268: 42.41