HitPredict

Interactor 1: MED26 (O95402)
Mediator of RNA polymerase II transcription subunit 26 (Activator-recruited cofactor 70 kDa component) (ARC70) (Cofactor required for Sp1 transcriptional activation subunit 7) (CRSP complex subunit 7) (Mediator complex subunit 26) (Transcriptional coactivator CRSP70)
Gene: MED26

Interactor 2: MED21 (Q13503)
Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (RNA polymerase II holoenzyme component SRB7) (RNAPII complex component SRB7) (hSrb7)
Gene: MED21

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 0.90 0.924

The method score is based on:

Property Details
Experiments 28514442, 24981860, 33961781, 35271311, 15175163, 24882805, 21729782, unassigned3799
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Med21~Med26_C
Common GO terms GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II
and 5 others

more...
Homologous interactions 0

Service provided by Combinatics, Japan

Last updated: 11Aug2025