Interactor 1: FA8 (P00451)
Coagulation factor VIII (Antihemophilic factor) (AHF) (Procoagulant component) [Cleaved into: Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain]
Gene: F8

Interactor 2: VWF (P04275)
von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)]
Gene: VWF

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.79 1.00 0.893

The method score is based on:

Property Details
Experiments 9218428, 18492805, 8562925, 27749002
Identification Methods pull down, enzyme linked immunosorbent assay, solid phase assay, surface plasmon resonance
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains F5_F8_type_C~TIL, F5_F8_type_C~VWD
Common GO terms GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0007596 - blood coagulation
GO:0031093 - platelet alpha granule lumen
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 2351
Hs

1 2813
+ Hs
+ Hs
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024