Interactor 1: RIR1 (P00452)
Ribonucleoside-diphosphate reductase 1 subunit alpha (EC 1.17.4.1) (Protein B1) (Ribonucleoside-diphosphate reductase 1 R1 subunit) (Ribonucleotide reductase 1)
Gene: nrdA

Interactor 2: RIR1 (P00452)
Ribonucleoside-diphosphate reductase 1 subunit alpha (EC 1.17.4.1) (Protein B1) (Ribonucleoside-diphosphate reductase 1 R1 subunit) (Ribonucleotide reductase 1)
Gene: nrdA

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.63 1.00 0.799

The method score is based on:

Property Details
Experiments 17726094, 22160671
Identification Methods molecular sieving, cosedimentation in solution, x ray scattering
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains ATP-cone~ATP-cone, ATP-cone~Ribonuc_red_lgC, ATP-cone~Ribonuc_red_lgN, Ribonuc_red_lgC~Ribonuc_red_lgC, Ribonuc_red_lgC~Ribonuc_red_lgN
Common GO terms GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0005971 - ribonucleoside-diphosphate reductase complex
GO:0006260 - DNA replication
and 5 others

more...

Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 761
Ec

1 761
+ Sc
+ Sc
+ Hs
+ Vv
+ Ha
+ Hh
+ Hh
+ Ha
+ Mb

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Last updated: 15 Jul 2024