HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0004672 - protein kinase activity GO:0005524 - ATP binding GO:0051402 - neuron apoptotic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 1342
+	Hs
		601837 ABL2_HUMAN (10-1130): 0: 775: 52.62		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		337480 ABL1_HUMAN (1-1130): 0: 984: 100.00		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		337300 ABL1_HUMAN (1-1130): 0: 984: 100.00		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		337294 ABL1_HUMAN (1-1130): 0: 984: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		789067 ABL2_HUMAN (10-1130): 0: 775: 52.62		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		383673 ABL2_HUMAN (10-1130): 0: 775: 52.62		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		338083 ABL2_HUMAN (10-1130): 0: 775: 52.62		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337293 ABL1_HUMAN (1-1130): 0: 984: 100.00		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	Hs
		337360 ABL1_HUMAN (1-1130): 0: 984: 100.00		EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00
+	Mm
		337615 ABL1_MOUSE (1-1130): 0: 901: 85.00		ABL1_MOUSE (696-1296): 5.65e-125: 417: 22.21
+	Mm
		337625 ABL1_MOUSE (1-1130): 0: 901: 85.00		EPHA4_MOUSE (656-996): 1.58e-103: 354: 27.79
+	Mm
		872619 ABL2_MOUSE (10-1130): 0: 766: 52.45		EPHB2_MOUSE (627-1004): 2.65e-117: 392: 26.40
+	Hs
		337384 ABL1_HUMAN (1-1130): 0: 984: 100.00		ABL2_HUMAN (705-971): 7.69e-43: 173: 36.06
+	Hs
		337359 ABL1_HUMAN (1-1130): 0: 984: 100.00		EPHA3_HUMAN (691-978): 1.41e-41: 168: 34.13
+	Hs
		665558 ABL2_HUMAN (10-1130): 0: 775: 52.62		EPHB2_HUMAN (635-993): 1.41e-105: 362: 28.00
+	Hs
		789049 ABL2_HUMAN (10-1130): 0: 775: 52.62		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Hs
		789042 ABL2_HUMAN (10-1130): 0: 775: 52.62		ABL2_HUMAN (705-971): 7.69e-43: 173: 36.06
+	Rn
		936859 SRC_RAT (13-510): 0: 549: 38.11		FAK2_RAT (673-1201): 4.11e-117: 392: 24.63
+	Dm
		337642 ABL_DROME (38-1092): 0: 583: 39.20		EGFR_DROME (347-637): 4.79e-14: 79.5: 20.27