HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.949

Property	Details
Experiments	15696159, 25852190, 33961781, 35271311, 16888623, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 246
+	Hs
		337416 ABL1_HUMAN (1-1130): 0: 984: 100.00		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		337420 ABL1_HUMAN (1-1130): 0: 984: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		337355 ABL1_HUMAN (1-1130): 0: 984: 100.00		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		337415 ABL1_HUMAN (1-1130): 0: 984: 100.00		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		337436 ABL1_HUMAN (1-1130): 0: 984: 100.00		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		337367 ABL1_HUMAN (1-1130): 0: 984: 100.00		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		789053 ABL2_HUMAN (10-1130): 0: 775: 52.62		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		683185 ABL2_HUMAN (10-1130): 0: 775: 52.62		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		789056 ABL2_HUMAN (10-1130): 0: 775: 52.62		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		646706 ABL2_HUMAN (10-1130): 0: 775: 52.62		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		789052 ABL2_HUMAN (10-1130): 0: 775: 52.62		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		789060 ABL2_HUMAN (10-1130): 0: 775: 52.62		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		683884 ABL2_HUMAN (10-1130): 0: 775: 52.62		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		411661 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		411666 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		411605 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		909481 ITK_HUMAN (44-499): 1.16e-153: 474: 34.74		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		411616 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		683983 BTK_HUMAN (5-501): 5.05e-156: 481: 36.56		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		683994 ITK_HUMAN (44-499): 1.16e-153: 474: 34.74		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62