HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	36931259, 16888623, 15696159
Identification Methods	proximity labelling technology, affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0051726 - regulation of cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 248
+	Hs
		337416 ABL1_HUMAN (1-1130): 0: 984: 100.00		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		337420 ABL1_HUMAN (1-1130): 0: 984: 100.00		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		337355 ABL1_HUMAN (1-1130): 0: 984: 100.00		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		337366 ABL1_HUMAN (1-1130): 0: 984: 100.00		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		337415 ABL1_HUMAN (1-1130): 0: 984: 100.00		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		337436 ABL1_HUMAN (1-1130): 0: 984: 100.00		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		683884 ABL2_HUMAN (10-1130): 0: 775: 52.62		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		789053 ABL2_HUMAN (10-1130): 0: 775: 52.62		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		789056 ABL2_HUMAN (10-1130): 0: 775: 52.62		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		646706 ABL2_HUMAN (10-1130): 0: 775: 52.62		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		683185 ABL2_HUMAN (10-1130): 0: 775: 52.62		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		789052 ABL2_HUMAN (10-1130): 0: 775: 52.62		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		789060 ABL2_HUMAN (10-1130): 0: 775: 52.62		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Hs
		411616 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		411661 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		683983 BTK_HUMAN (5-501): 5.05e-156: 481: 36.56		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		411666 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		683994 ITK_HUMAN (44-499): 1.16e-153: 474: 34.74		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		909481 ITK_HUMAN (44-499): 1.16e-153: 474: 34.74		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		411605 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85