HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

The method score is based on:

Property	Details
Experiments	12024016, 17352427
Identification Methods	affinity chromatography technology, pull down, enzymatic study, fluorescent resonance energy transfer, bimolecular fluorescence complementation
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003713 - transcription coactivator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 6 others more... GO:0006974 - DNA damage response GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0016604 - nuclear body GO:0032991 - protein-containing complex GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051726 - regulation of cell cycle
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	1130
Hs

1	1863

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024