HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: 1433E (P62258)
14-3-3 protein epsilon (14-3-3E)
Gene: YWHAE

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.930

Property	Details
Experiments	15696159, 25852190, 35271311, 36931259, 16888623
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 255
+	Hs
		789053 ABL2_HUMAN (10-1130): 0: 775: 52.62		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		411661 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		909481 ITK_HUMAN (44-499): 1.16e-153: 474: 34.74		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00
+	Hs
		782766 CSK_HUMAN (61-500): 1.81e-155: 472: 37.72		1433E_HUMAN (1-255): 4.87e-154: 430: 100.00