HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9006901
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, SH2~SH2, PH~SH3_1, SH2~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032991 - protein-containing complex GO:0070371 - ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 594
+	Hs
		337333 ABL1_HUMAN (1-1130): 0: 984: 100.00		VAV_HUMAN (36-594): 3.93e-139: 426: 14.11
+	Hs
		337307 ABL1_HUMAN (1-1130): 0: 984: 100.00		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		337329 ABL1_HUMAN (1-1130): 0: 984: 100.00		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08
+	Hs
		337315 ABL1_HUMAN (1-1130): 0: 984: 100.00		HCK_HUMAN (406-593): 7.97e-46: 171: 18.78
+	Hs
		337466 ABL1_HUMAN (1-1130): 0: 984: 100.00		GRAP_HUMAN (489-575): 4.78e-25: 105: 32.18
+	Hs
		337418 ABL1_HUMAN (1-1130): 0: 984: 100.00		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		69206 A9UF07_HUMAN (25-1130): 0: 945: 99.73		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		412070 ABL2_HUMAN (10-1130): 0: 775: 52.62		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		522840 ABL2_HUMAN (10-1130): 0: 775: 52.62		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08
+	Hs
		442789 ABL2_HUMAN (10-1130): 0: 775: 52.62		HCK_HUMAN (406-593): 7.97e-46: 171: 18.78
+	Hs
		789054 ABL2_HUMAN (10-1130): 0: 775: 52.62		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		411573 SRC_HUMAN (13-510): 0: 547: 38.58		LCK_HUMAN (420-589): 7.66e-49: 179: 19.66
+	Rn
		1376717 SRC_RAT (13-510): 0: 549: 38.11		SRC_RAT (443-590): 9.65e-47: 174: 22.08
+	Gg
		337663 SRC_CHICK (10-510): 0: 547: 37.97		SRC_CHICK (408-590): 1.04e-47: 176: 20.21
+	Hs
		411969 SRC_HUMAN (13-510): 0: 547: 38.58		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		433231 SRC_HUMAN (13-510): 0: 547: 38.58		YES_HUMAN (441-592): 9.17e-47: 174: 20.89
+	Rn
		989767 SRC_RAT (13-510): 0: 549: 38.11		LYN_RAT (409-593): 1.82e-46: 172: 17.19
+	Hs
		433546 SRC_HUMAN (13-510): 0: 547: 38.58		LYN_HUMAN (409-593): 7.45e-46: 171: 17.19
+	Hs
		442772 SRC_HUMAN (13-510): 0: 547: 38.58		HCK_HUMAN (406-593): 7.97e-46: 171: 18.78
+	Rn
		693648 SRC_RAT (13-510): 0: 549: 38.11		CSK_RAT (454-587): 1.89e-26: 114: 23.19