HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: GRAP (Q13588)
GRB2-related adapter protein
Gene: GRAP

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8647802
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, SH2~SH2, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 217
+	Hs
		337418 ABL1_HUMAN (1-1130): 0: 984: 100.00		GRB2_HUMAN (1-216): 4.15e-69: 212: 59.72
+	Hs
		337293 ABL1_HUMAN (1-1130): 0: 984: 100.00		ABL1_HUMAN (3-180): 4.01e-52: 182: 31.69
+	Hs
		337315 ABL1_HUMAN (1-1130): 0: 984: 100.00		HCK_HUMAN (4-158): 6.34e-52: 176: 32.74
+	Hs
		69206 A9UF07_HUMAN (25-1130): 0: 945: 99.73		GRB2_HUMAN (1-216): 4.15e-69: 212: 59.72
+	Hs
		337337 ABL1_HUMAN (1-1130): 0: 984: 100.00		NCK1_HUMAN (5-145): 1.04e-23: 99: 35.47
+	Mm
		337615 ABL1_MOUSE (1-1130): 0: 901: 85.00		ABL1_MOUSE (3-180): 4.04e-52: 182: 31.69
+	Hs
		337384 ABL1_HUMAN (1-1130): 0: 984: 100.00		ABL2_HUMAN (4-137): 3.81e-23: 98.6: 38.13
+	Hs
		337333 ABL1_HUMAN (1-1130): 0: 984: 100.00		VAV_HUMAN (2-60): 1.27e-16: 80: 33.90
+	Hs
		337608 ABL1_HUMAN (1-1130): 0: 984: 100.00		CD2AP_HUMAN (3-58): 7.12e-13: 68.8: 28.07
+	Hs
		298944 ABL1_HUMAN (1-1130): 0: 984: 100.00		SRBS2_HUMAN (69-216): 1.02e-12: 68.4: 21.33
+	Hs
		337307 ABL1_HUMAN (1-1130): 0: 984: 100.00		FYN_HUMAN (154-215): 1.46e-12: 67.7: 31.25
+	Hs
		275157 ABL1_HUMAN (1-1130): 0: 984: 100.00		GRAP2_HUMAN (3-55): 1.64e-11: 64.4: 33.96
+	Hs
		337329 ABL1_HUMAN (1-1130): 0: 984: 100.00		SRC_HUMAN (141-214): 3.55e-11: 63.8: 21.05
+	Mm
		337637 ABL1_MOUSE (1-1130): 0: 901: 85.00		NCK1_MOUSE (5-145): 1.5e-23: 98.2: 34.88
+	Hs
		442789 ABL2_HUMAN (10-1130): 0: 775: 52.62		HCK_HUMAN (4-158): 6.34e-52: 176: 32.74
+	Hs
		557630 ABL2_HUMAN (10-1130): 0: 775: 52.62		NCK1_HUMAN (5-145): 1.04e-23: 99: 35.47
+	Hs
		298959 ABL2_HUMAN (10-1130): 0: 775: 52.62		SRBS2_HUMAN (69-216): 1.02e-12: 68.4: 21.33
+	Hs
		412070 ABL2_HUMAN (10-1130): 0: 775: 52.62		FYN_HUMAN (154-215): 1.46e-12: 67.7: 31.25
+	Hs
		522840 ABL2_HUMAN (10-1130): 0: 775: 52.62		SRC_HUMAN (141-214): 3.55e-11: 63.8: 21.05