HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.46	1.00	0.680

Property	Details
Experiments	9593709
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0030036 - actin cytoskeleton organization GO:0051015 - actin filament binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 2472
+	Hs
		337296 ABL1_HUMAN (1-1130): 0: 984: 100.00		SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81
+	Hs
		411715 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Hs
		433753 LYN_HUMAN (9-508): 9.12e-173: 519: 36.15		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Hs
		360640 BTK_HUMAN (5-501): 5.05e-156: 481: 36.56		SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81
+	Hs
		164551 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		164555 LYN_HUMAN (9-508): 9.12e-173: 519: 36.15		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		297808 LYN_HUMAN (9-508): 9.12e-173: 519: 36.15		K0754_HUMAN (1-1482): 9.32e-58: 225: 14.65
+	Hs
		411676 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		433700 LYN_HUMAN (9-508): 9.12e-173: 519: 36.15		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		411724 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57
+	Hs
		411682 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		433710 LYN_HUMAN (9-508): 9.12e-173: 519: 36.15		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		411889 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48
+	Hs
		521454 SRC_HUMAN (13-510): 0: 547: 38.58		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25
+	Hs
		211480 SRC_HUMAN (13-510): 0: 547: 38.58		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		434078 LYN_HUMAN (9-508): 9.12e-173: 519: 36.15		MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48
+	Hs
		521527 BTK_HUMAN (5-501): 5.05e-156: 481: 36.56		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25