HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: FLNC (Q14315)
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)
Gene: FLNC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0051015 - actin filament binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 2725
+	Hs
		412192 FYN_HUMAN (18-510): 0: 543: 38.64		FLNC_HUMAN (1-2725): 0: 2507: 100.00
+	Hs
		337345 ABL1_HUMAN (1-1130): 0: 984: 100.00		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		522770 SRC_HUMAN (13-510): 0: 547: 38.58		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		412006 FYN_HUMAN (18-510): 0: 543: 38.64		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		598078 BTK_HUMAN (5-501): 5.05e-156: 481: 36.56		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		521454 SRC_HUMAN (13-510): 0: 547: 38.58		ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30
+	Hs
		211480 SRC_HUMAN (13-510): 0: 547: 38.58		ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68
+	Hs
		411676 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12
+	Hs
		521527 BTK_HUMAN (5-501): 5.05e-156: 481: 36.56		ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30
+	Hs
		433700 LYN_HUMAN (9-508): 9.12e-173: 519: 36.15		SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12
+	Hs
		362685 FYN_HUMAN (18-510): 0: 543: 38.64		FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83
+	Hs
		362705 YES_HUMAN (5-510): 3.73e-179: 537: 39.42		FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83