HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: SHB (Q15464)
SH2 domain-containing adapter protein B
Gene: SHB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.747

Property	Details
Experiments	17112510
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045931 - positive regulation of mitotic cell cycle GO:0050852 - T cell receptor signaling pathway
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 509
+	Hs
		337531 ABL1_HUMAN (1-1130): 0: 984: 100.00		SHD_HUMAN (76-508): 3.86e-78: 250: 37.01
+	Hs
		337362 ABL1_HUMAN (1-1130): 0: 984: 100.00		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		337329 ABL1_HUMAN (1-1130): 0: 984: 100.00		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		337315 ABL1_HUMAN (1-1130): 0: 984: 100.00		HCK_HUMAN (261-507): 1.14e-54: 193: 15.75
+	Hs
		337337 ABL1_HUMAN (1-1130): 0: 984: 100.00		NCK1_HUMAN (157-504): 3.1e-55: 191: 14.25
+	Hs
		337307 ABL1_HUMAN (1-1130): 0: 984: 100.00		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32
+	Hs
		337491 ABL1_HUMAN (1-1130): 0: 984: 100.00		SHE_HUMAN (51-508): 1.23e-53: 190: 27.77
+	Hs
		69203 A9UF07_HUMAN (25-1130): 0: 945: 99.73		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		337418 ABL1_HUMAN (1-1130): 0: 984: 100.00		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		337384 ABL1_HUMAN (1-1130): 0: 984: 100.00		ABL2_HUMAN (354-487): 6.99e-36: 144: 26.12
+	Hs
		337293 ABL1_HUMAN (1-1130): 0: 984: 100.00		ABL1_HUMAN (354-507): 1.09e-35: 143: 24.03
+	Hs
		69206 A9UF07_HUMAN (25-1130): 0: 945: 99.73		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Mm
		337637 ABL1_MOUSE (1-1130): 0: 901: 85.00		NCK1_MOUSE (157-504): 4.76e-55: 191: 14.80
+	Hs
		275157 ABL1_HUMAN (1-1130): 0: 984: 100.00		GRAP2_HUMAN (354-490): 4.56e-18: 87.3: 24.64
+	Hs
		337466 ABL1_HUMAN (1-1130): 0: 984: 100.00		GRAP_HUMAN (354-490): 1.31e-17: 83.5: 20.86
+	Mm
		337615 ABL1_MOUSE (1-1130): 0: 901: 85.00		ABL1_MOUSE (354-507): 2.92e-35: 142: 24.03
+	Hs
		209001 ABL2_HUMAN (10-1130): 0: 775: 52.62		NCK2_HUMAN (157-505): 7.36e-63: 211: 17.45
+	Hs
		442789 ABL2_HUMAN (10-1130): 0: 775: 52.62		HCK_HUMAN (261-507): 1.14e-54: 193: 15.75
+	Hs
		412070 ABL2_HUMAN (10-1130): 0: 775: 52.62		FYN_HUMAN (280-506): 1.72e-53: 190: 15.32