HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: LRRK1 (Q38SD2)
Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1)
Gene: LRRK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.857

Property	Details
Experiments	29513927, 20697350, 24947832
Identification Methods	pull down, affinity chromatography technology, protein array
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	COR~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0050731 - positive regulation of peptidyl-tyrosine phosphorylation
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 2015
+	Hs
		788997 TEC_HUMAN (40-502): 5.28e-154: 475: 36.71		LRRK1_HUMAN (1-2015): 0: 1859: 99.60
+	Hs
		337490 ABL1_HUMAN (1-1130): 0: 984: 100.00		LRRK2_HUMAN (47-285): 1.02e-20: 102: 11.65
+	Hs
		69197 A9UEZ6_HUMAN (87-1130): 0: 886: 99.81		LRRK2_HUMAN (47-285): 1.02e-20: 102: 11.65
+	Hs
		789074 ABL2_HUMAN (10-1130): 0: 775: 52.62		LRRK2_HUMAN (47-285): 1.02e-20: 102: 11.65
+	Hs
		789058 ABL2_HUMAN (10-1130): 0: 775: 52.62		M3K10_HUMAN (1247-1521): 1.17e-20: 101: 32.41
+	Hs
		66464 A8K3B6_HUMAN (61-500): 2.08e-155: 472: 37.72		LRRK2_HUMAN (47-285): 1.02e-20: 102: 11.65