HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.641

Property	Details
Experiments	19914245, 28141795
Identification Methods	affinity chromatography technology, far western blotting, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0005739 - mitochondrion GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1130 Hs			1 540
+	Hs
		337496 ABL1_HUMAN (1-1130): 0: 984: 100.00		HUWE1_HUMAN (79-539): 8.05e-24: 108: 13.36
+	Hs
		337590 ABL1_HUMAN (1-1130): 0: 984: 100.00		ASAP1_HUMAN (95-423): 4.61e-23: 105: 13.43
+	Hs
		337335 ABL1_HUMAN (1-1130): 0: 984: 100.00		MUC1_HUMAN (160-534): 7.43e-16: 83.3: 10.90
+	Hs
		523040 SRC_HUMAN (13-510): 0: 547: 38.58		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Hs
		297808 LYN_HUMAN (9-508): 9.12e-173: 519: 36.15		K0754_HUMAN (43-539): 5.17e-38: 151: 11.24
+	Hs
		523197 SRC_HUMAN (13-510): 0: 547: 38.58		ASAP1_HUMAN (95-423): 4.61e-23: 105: 13.43
+	Hs
		412404 FYN_HUMAN (18-510): 0: 543: 38.64		ASAP1_HUMAN (95-423): 4.61e-23: 105: 13.43
+	Hs
		442894 HCK_HUMAN (9-508): 5.18e-175: 526: 38.79		ASAP1_HUMAN (95-423): 4.61e-23: 105: 13.43
+	Hs
		522749 SRC_HUMAN (13-510): 0: 547: 38.58		MUC1_HUMAN (160-534): 7.43e-16: 83.3: 10.90
+	Hs
		433853 LYN_HUMAN (9-508): 9.12e-173: 519: 36.15		MICA3_HUMAN (68-506): 7.25e-20: 96: 12.82
+	Hs
		411582 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		MUC1_HUMAN (160-534): 7.43e-16: 83.3: 10.90
+	Hs
		523118 SRC_HUMAN (13-510): 0: 547: 38.58		CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58
+	Hs
		412362 FYN_HUMAN (18-510): 0: 543: 38.64		MAGE1_HUMAN (183-537): 6.13e-11: 67.2: 9.58
+	Hs
		433560 LYN_HUMAN (9-508): 9.12e-173: 519: 36.15		MUC1_HUMAN (160-534): 7.43e-16: 83.3: 10.90
+	Hs
		203198 LCK_HUMAN (9-508): 3.02e-177: 531: 38.49		SYNJ1_HUMAN (196-539): 7.02e-12: 70.6: 13.41
+	Mm
		101424 LYN_MOUSE (9-508): 4.68e-172: 517: 35.77		F8VPR5_MOUSE (82-395): 1.45e-11: 69.8: 14.24
+	Hs
		789012 TEC_HUMAN (40-502): 5.28e-154: 475: 36.71		ASAP1_HUMAN (95-423): 4.61e-23: 105: 13.43
+	Mm
		101430 CSK_MOUSE (61-500): 2.58e-155: 472: 37.95		F8VPR5_MOUSE (82-395): 1.45e-11: 69.8: 14.24
+	Hs
		782820 CSK_HUMAN (61-500): 1.81e-155: 472: 37.72		CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58