HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: ABI1 (Q8IZP0)
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)
Gene: ABI1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.974

Property	Details
Experiments	18328268, 9010225, 12672821, 11418237, 9593709, 17101133, 20598684
Identification Methods	enzymatic study, affinity chromatography technology, pull down, filter binding, two hybrid, anti bait coimmunoprecipitation, far western blotting, surface plasmon resonance, anti tag coimmunoprecipitation, fluorescence technology and 1 others more... array technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0017124 - SH3 domain binding GO:0030426 - growth cone
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 508
+	Mm
		337634 ABL1_MOUSE (1-1130): 0: 901: 85.00		ABI1_MOUSE (1-508): 1.42e-122: 369: 91.93
+	Hs
		337572 ABL1_HUMAN (1-1130): 0: 984: 100.00		ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84
+	Hs
		789078 ABL2_HUMAN (10-1130): 0: 775: 52.62		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		337590 ABL1_HUMAN (1-1130): 0: 984: 100.00		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Hs
		166023 ABL1_HUMAN (1-1130): 0: 984: 100.00		SYNJ2_HUMAN (39-458): 2.1e-26: 115: 13.88
+	Hs
		235462 ABL1_HUMAN (1-1130): 0: 984: 100.00		VINEX_HUMAN (229-504): 5.02e-15: 79.8: 15.58
+	Hs
		337608 ABL1_HUMAN (1-1130): 0: 984: 100.00		CD2AP_HUMAN (451-508): 2.26e-14: 77.9: 40.68
+	Hs
		789094 ABL2_HUMAN (10-1130): 0: 775: 52.62		ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84
+	Hs
		523060 SRC_HUMAN (13-510): 0: 547: 38.58		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		412258 FYN_HUMAN (18-510): 0: 543: 38.64		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		789066 ABL2_HUMAN (10-1130): 0: 775: 52.62		SRC8_HUMAN (291-502): 1.23e-34: 138: 20.72
+	Hs
		235483 ABL2_HUMAN (10-1130): 0: 775: 52.62		VINEX_HUMAN (229-504): 5.02e-15: 79.8: 15.58
+	Dm
		337662 ABL_DROME (38-1092): 0: 583: 39.20		Q9Y0S9_DROME (1-504): 2.01e-77: 252: 34.72
+	Ce
		371307 ABL1_CAEEL (3-1130): 0: 606: 32.11		Q10929_CAEEL (3-503): 2.93e-67: 225: 28.94
+	Hs
		522981 SRC_HUMAN (13-510): 0: 547: 38.58		SRC8_HUMAN (291-502): 1.23e-34: 138: 20.72
+	Hs
		523197 SRC_HUMAN (13-510): 0: 547: 38.58		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Hs
		412404 FYN_HUMAN (18-510): 0: 543: 38.64		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Mm
		763381 FYN_MOUSE (18-510): 0: 542: 38.64		HCLS1_MOUSE (266-503): 2.48e-29: 122: 20.07
+	Hs
		166024 FYN_HUMAN (18-510): 0: 543: 38.64		SYNJ2_HUMAN (39-458): 2.1e-26: 115: 13.88
+	Hs
		412426 FYN_HUMAN (18-510): 0: 543: 38.64		CD2AP_HUMAN (451-508): 2.26e-14: 77.9: 40.68