HitPredict

Interactor 1: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19531213
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 665
+	Hs
		337608 ABL1_HUMAN (1-1130): 0: 984: 100.00		CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22
+	Hs
		337337 ABL1_HUMAN (1-1130): 0: 984: 100.00		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		337418 ABL1_HUMAN (1-1130): 0: 984: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		69206 A9UF07_HUMAN (25-1130): 0: 945: 99.73		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		275157 ABL1_HUMAN (1-1130): 0: 984: 100.00		GRAP2_HUMAN (1-56): 2.18e-17: 85.8: 32.14
+	Hs
		235462 ABL1_HUMAN (1-1130): 0: 984: 100.00		VINEX_HUMAN (67-445): 2.37e-15: 81.7: 19.82
+	Hs
		337333 ABL1_HUMAN (1-1130): 0: 984: 100.00		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95
+	Hs
		298944 ABL1_HUMAN (1-1130): 0: 984: 100.00		SRBS2_HUMAN (3-155): 4.65e-11: 68.2: 30.86
+	Mm
		337637 ABL1_MOUSE (1-1130): 0: 901: 85.00		NCK1_MOUSE (104-421): 1.23e-32: 131: 15.93
+	Hs
		523104 SRC_HUMAN (13-510): 0: 547: 38.58		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		412296 FYN_HUMAN (18-510): 0: 543: 38.64		SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00
+	Hs
		557630 ABL2_HUMAN (10-1130): 0: 775: 52.62		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		789054 ABL2_HUMAN (10-1130): 0: 775: 52.62		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		209001 ABL2_HUMAN (10-1130): 0: 775: 52.62		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Hs
		235483 ABL2_HUMAN (10-1130): 0: 775: 52.62		VINEX_HUMAN (67-445): 2.37e-15: 81.7: 19.82
+	Hs
		298959 ABL2_HUMAN (10-1130): 0: 775: 52.62		SRBS2_HUMAN (3-155): 4.65e-11: 68.2: 30.86
+	Hs
		523022 SRC_HUMAN (13-510): 0: 547: 38.58		SPD2A_HUMAN (1-631): 1.05e-46: 180: 14.72
+	Hs
		522887 SRC_HUMAN (13-510): 0: 547: 38.58		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		411986 FYN_HUMAN (18-510): 0: 543: 38.64		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		411981 FYN_HUMAN (18-510): 0: 543: 38.64		VAV_HUMAN (84-158): 4.66e-13: 74.7: 28.95