HitPredict

Interactor 1: SRC64 (P00528)
Tyrosine-protein kinase Src64B (Dsrc64) (EC 2.7.10.2)
Gene: Src64B

Interactor 2: EGRAP (Q6NR09)
EGFR adapter protein
Gene: Egfrap

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.80	0.587

Property	Details
Experiments	14605208
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 552 Dm			1 421
+	Dm
		337669 SRC64_DROME (1-552): 0: 592: 100.00		BTKL_DROME (3-421): 7.8e-63: 217: 12.98
+	Hs
		433231 YES_HUMAN (5-549): 0: 565: 45.42		SRC_HUMAN (148-421): 3.35e-69: 229: 15.46
+	Hs
		433215 YES_HUMAN (5-549): 0: 565: 45.42		YES_HUMAN (137-421): 1.45e-66: 223: 16.13
+	Hs
		411946 YES_HUMAN (5-549): 0: 565: 45.42		FYN_HUMAN (158-421): 2.28e-65: 219: 14.73
+	Dm
		337668 SRC64_DROME (1-552): 0: 592: 100.00		SRC64_DROME (163-421): 1.49e-53: 189: 16.61
+	Hs
		411969 FYN_HUMAN (31-549): 0: 550: 45.79		SRC_HUMAN (148-421): 3.35e-69: 229: 15.46
+	Dm
		337700 SRC64_DROME (1-552): 0: 592: 100.00		Q9VGK8_DROME (49-418): 1.77e-50: 184: 13.81
+	Gg
		337663 SRC_CHICK (20-549): 0: 545: 48.04		SRC_CHICK (148-421): 2.53e-69: 230: 17.22
+	Hs
		433222 YES_HUMAN (5-549): 0: 565: 45.42		FGR_HUMAN (181-421): 9.03e-62: 210: 16.98
+	Hs
		433216 YES_HUMAN (5-549): 0: 565: 45.42		LYN_HUMAN (137-421): 2.51e-61: 208: 16.50
+	Hs
		411552 YES_HUMAN (5-549): 0: 565: 45.42		LCK_HUMAN (187-421): 3.8e-60: 205: 18.58
+	Hs
		411936 FYN_HUMAN (31-549): 0: 550: 45.79		FYN_HUMAN (158-421): 2.28e-65: 219: 14.73
+	Dm
		337705 SRC64_DROME (1-552): 0: 592: 100.00		Q9VRS2_DROME (61-421): 6.49e-49: 174: 43.16
+	Hs
		411545 FYN_HUMAN (31-549): 0: 550: 45.79		LCK_HUMAN (187-421): 3.8e-60: 205: 18.58
+	Hs
		412071 FYN_HUMAN (31-549): 0: 550: 45.79		FRK_HUMAN (189-421): 4.93e-55: 191: 18.11
+	Hs
		412147 FYN_HUMAN (31-549): 0: 550: 45.79		BTK_HUMAN (185-421): 2.87e-50: 181: 16.92
+	Hs
		412070 FYN_HUMAN (31-549): 0: 550: 45.79		ABL2_HUMAN (121-421): 3.81e-47: 175: 15.96
+	Hs
		337307 FYN_HUMAN (31-549): 0: 550: 45.79		ABL1_HUMAN (281-384): 1.65e-29: 123: 30.77
+	Hs
		412066 FYN_HUMAN (31-549): 0: 550: 45.79		CSK_HUMAN (260-379): 2.66e-21: 97.3: 24.17