HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 189
+	Mm
		699617 EGFR_MOUSE (1-1210): 0: 1258: 90.35		RASK_MOUSE (1-189): 3.25e-85: 251: 87.90
+	Hs
		337724 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		338459 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71
+	Hs
		337723 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Hs
		338247 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RAB1A_HUMAN (4-187): 1.35e-76: 229: 33.33
+	Hs
		338238 EGFR_HUMAN (1-1210): 0: 1241: 100.00		RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88
+	Hs
		349789 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		383819 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71
+	Hs
		349057 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Hs
		383971 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		RAB1B_HUMAN (4-187): 1.35e-75: 226: 33.51
+	Hs
		350003 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		349905 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		665604 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71
+	Hs
		350187 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Hs
		1070202 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71
+	Hs
		349222 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Hs
		348673 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		RASN_HUMAN (1-189): 9.9e-80: 236: 100.00
+	Hs
		348527 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		RASN_HUMAN (1-189): 9.9e-80: 236: 100.00
+	Hs
		665570 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52
+	Hs
		895087 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52