Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Interactor 2: TGFA (P01135)
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1)]
Gene: TGFA
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.91 | 0.60 | 0.743 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25402006, 24658140, 12297049, 8663070, 10775655, unassigned2173, 28988771 |
| Identification Methods | two hybrid, protein complementation assay, x-ray crystallography, biochemical, biophysical, ubiquitin reconstruction, x ray scattering |
| Interaction Type | direct interaction, association, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005615 - extracellular space GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0007173 - epidermal growth factor receptor signaling pathway GO:0008284 - positive regulation of cell population proliferation and 7 others more... |
| Homologous interactions | 16 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
