HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	24780295, 26320552
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0031965 - nuclear membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 664
+	Hs
		337855 EGFR_HUMAN (1-1210): 0: 1241: 100.00		K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95
+	Hs
		337731 EGFR_HUMAN (1-1210): 0: 1241: 100.00		K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71
+	Hs
		337806 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VIME_HUMAN (27-389): 3.94e-31: 129: 28.93
+	Hs
		213922 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KRT86_HUMAN (250-556): 7.5e-10: 63.7: 12.93
+	Hs
		535327 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43
+	Hs
		380436 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51
+	Hs
		443382 ABL2_HUMAN (707-974): 5.53e-52: 202: 40.37		VIME_HUMAN (27-389): 3.94e-31: 129: 28.93
+	Hs
		537730 INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90		KRT83_HUMAN (250-560): 7.81e-11: 66.8: 13.08