HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: K2C1 (P04264)
Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)
Gene: KRT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	28065597, 15657067
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 644
+	Hs
		213922 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KRT86_HUMAN (79-558): 5.38e-84: 274: 43.69
+	Hs
		337855 EGFR_HUMAN (1-1210): 0: 1241: 100.00		K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32
+	Hs
		337731 EGFR_HUMAN (1-1210): 0: 1241: 100.00		K2C6A_HUMAN (2-512): 2.12e-75: 253: 62.43
+	Hs
		337847 EGFR_HUMAN (1-1210): 0: 1241: 100.00		K2C3_HUMAN (152-497): 1.64e-62: 220: 74.71
+	Hs
		537730 INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90		KRT83_HUMAN (79-563): 3.51e-87: 282: 44.47
+	Hs
		380436 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		K2C6B_HUMAN (2-512): 5.16e-79: 263: 62.82