Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR
Interactor 2: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.98 | 1.00 | 0.991 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 20211985, 18803307, 8665853, 9461599, 7797556, 1346931, 11526509, 30898150, 25898135, 19060928, 17486068, 24189400, 25315821, 7531698, 32669362, 16207817, 17307140, 11408594, 21044682, 21203579 and 7 others
more... |
| Identification Methods | affinity chromatography technology, pull down, unspecified method, protein complementation assay, two hybrid, anti bait coimmunoprecipitation, beta galactosidase complementation, protein kinase assay, tandem affinity purification, protein cross-linking with a bifunctional reagent |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Furin-like~Furin-like, Furin-like~GF_recep_IV, Furin-like~Recep_L_domain, GF_recep_IV~GF_recep_IV, GF_recep_IV~Recep_L_domain, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, Recep_L_domain~Recep_L_domain |
| Common GO terms | GO:0001934 - positive regulation of protein phosphorylation GO:0004713 - protein tyrosine kinase activity GO:0004714 - transmembrane receptor protein tyrosine kinase activity GO:0004888 - transmembrane signaling receptor activity GO:0005524 - ATP binding and 22 others more... |
| Homologous interactions | 19 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
