HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: KPCB (P05771)
Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)
Gene: PRKCB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	9815893
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0003682 - chromatin binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane and 1 others more... GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 671
+	Hs
		337891 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KPCA_HUMAN (1-668): 0: 742: 78.89
+	Hs
		338299 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KPCE_HUMAN (5-662): 0: 624: 44.73
+	Hs
		338004 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33
+	Hs
		338005 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AKT2_HUMAN (237-665): 2.34e-159: 469: 37.87
+	Hs
		383640 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33
+	Hs
		601822 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33
+	Hs
		338071 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KPCI_HUMAN (10-86): 4.39e-13: 74.3: 40.26
+	Hs
		338314 EGFR_HUMAN (1-1210): 0: 1241: 100.00		KPCZ_HUMAN (10-86): 4.47e-12: 71.2: 36.36
+	Hs
		397152 EPHB1_HUMAN (640-1071): 8.83e-123: 405: 28.06		KPCG_HUMAN (1-668): 0: 678: 66.96
+	Hs
		665151 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33
+	Hs
		537714 INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90		KPCA_HUMAN (1-668): 0: 742: 78.89
+	Mm
		546263 INSR_MOUSE (428-1032): 4.47e-109: 375: 19.65		AKT1_MOUSE (239-665): 1.05e-159: 470: 37.33
+	Mm
		554948 FAK2_MOUSE (716-974): 4.22e-52: 201: 37.64		KPCE_MOUSE (5-662): 0: 624: 45.02
+	Hs
		681809 ACK1_HUMAN (691-967): 4.54e-56: 214: 39.58		AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33
+	Rn
		936858 FAK2_RAT (716-974): 2.97e-52: 202: 37.64		AKT3_RAT (284-665): 5.29e-156: 460: 41.48
+	Hs
		616681 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		KS6B1_HUMAN (291-671): 1.04e-153: 456: 36.83
+	Hs
		411362 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		KPCD_HUMAN (6-167): 1.49e-54: 199: 40.83
+	Hs
		784013 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		KPCI_HUMAN (10-86): 4.39e-13: 74.3: 40.26
+	Hs
		537733 INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90		KPCD_HUMAN (6-167): 1.49e-54: 199: 40.83
+	Hs
		783990 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		KPCI_HUMAN (10-86): 4.39e-13: 74.3: 40.26