HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: S10A9 (P06702)
Protein S100-A9 (Calgranulin-B) (Calprotectin L1H subunit) (Leukocyte L1 complex heavy chain) (Migration inhibitory factor-related protein 14) (MRP-14) (p14) (S100 calcium-binding protein A9)
Gene: S100A9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.51	0.60	0.554

Property	Details
Experiments	16799092
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0030307 - positive regulation of cell growth
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 114
+	Hs
		338011 EGFR_HUMAN (1-1210): 0: 1241: 100.00		S10AB_HUMAN (6-101): 7.08e-36: 120: 34.38
+	Hs
		338660 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HORN_HUMAN (5-97): 3.47e-32: 120: 29.03
+	Hs
		337962 EGFR_HUMAN (1-1210): 0: 1241: 100.00		S10A4_HUMAN (7-101): 5.27e-33: 112: 29.47
+	Hs
		338220 EGFR_HUMAN (1-1210): 0: 1241: 100.00		S10AA_HUMAN (6-104): 6.27e-32: 109: 29.29
+	Hs
		338001 EGFR_HUMAN (1-1210): 0: 1241: 100.00		S10A7_HUMAN (6-105): 8.64e-26: 94.2: 24.75
+	Hs
		685170 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		S10AB_HUMAN (6-101): 7.08e-36: 120: 34.38
+	Hs
		642945 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		S10A4_HUMAN (7-101): 5.27e-33: 112: 29.47
+	Hs
		893799 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		S10AA_HUMAN (6-104): 6.27e-32: 109: 29.29
+	Hs
		383643 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		S10AB_HUMAN (6-101): 7.08e-36: 120: 34.38
+	Hs
		383930 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		S10AG_HUMAN (1-101): 1.68e-28: 101: 23.53
+	Hs
		383989 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		S10AE_HUMAN (4-103): 3.68e-21: 82.7: 29.00
+	Hs
		601812 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		S10A4_HUMAN (7-101): 5.27e-33: 112: 29.47
+	Hs
		601869 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		S10AA_HUMAN (6-104): 6.27e-32: 109: 29.29
+	Hs
		380734 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		S100B_HUMAN (5-97): 2.99e-31: 107: 37.63
+	Hs
		416337 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		S10A9_HUMAN (1-114): 4.07e-47: 148: 100.00
+	Hs
		396674 INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90		S10A8_HUMAN (5-100): 3.01e-29: 102: 25.00