HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: TBB5 (P07437)
Tubulin beta chain (Tubulin beta-5 chain)
Gene: TUBB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	23956138, 15657067
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0031625 - ubiquitin protein ligase binding GO:0032991 - protein-containing complex GO:0045121 - membrane raft
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 444
+	Hs
		338386 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TBB3_HUMAN (1-444): 0: 712: 92.57
+	Hs
		338266 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TBB4B_HUMAN (1-427): 0: 707: 98.36
+	Hs
		338407 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TBB2A_HUMAN (1-430): 0: 704: 96.98
+	Hs
		338925 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TBB6_HUMAN (1-432): 0: 703: 92.13
+	Hs
		337745 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TBB4A_HUMAN (1-427): 0: 702: 97.42
+	Hs
		383959 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		TBB6_HUMAN (1-432): 0: 703: 92.13
+	Hs
		428019 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		TBB5_HUMAN (1-429): 0: 709: 100.00
+	Hs
		601930 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		TBB8_HUMAN (1-427): 0: 702: 89.70
+	Hs
		428109 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		TBB5_HUMAN (1-429): 0: 709: 100.00
+	Hs
		872631 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		TBB4B_HUMAN (1-427): 0: 707: 98.36
+	Hs
		872702 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		TBB2B_HUMAN (1-430): 0: 707: 97.44
+	Hs
		428222 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		TBB5_HUMAN (1-429): 0: 709: 100.00
+	Hs
		872701 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		TBB6_HUMAN (1-432): 0: 703: 92.13
+	Hs
		381152 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		TBB4A_HUMAN (1-427): 0: 702: 97.42
+	Hs
		1072512 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		TBB8_HUMAN (1-427): 0: 702: 89.70
+	Hs
		411272 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		TBB5_HUMAN (1-429): 0: 709: 100.00
+	Gg
		94429 KSYK_CHICK (718-961): 1.71e-55: 206: 41.30		TBB7_CHICK (1-429): 0: 709: 100.00
+	Hs
		428078 KSYK_HUMAN (716-961): 1.13e-53: 201: 41.70		TBB5_HUMAN (1-429): 0: 709: 100.00
+	Hs
		428077 ZAP70_HUMAN (718-961): 5.57e-53: 199: 39.59		TBB5_HUMAN (1-429): 0: 709: 100.00
+	Hs
		537737 INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90		TBB3_HUMAN (1-444): 0: 712: 92.57