HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PGS2 (P07585)
Decorin (Bone proteoglycan II) (PG-S2) (PG40)
Gene: DCN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	12105206, 9988678
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	GF_recep_IV~LRR_8, LRR_8~PK_Tyr_Ser-Thr
Common GO terms	GO:0005615 - extracellular space GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 359
+	Hs
		338583 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LRIG3_HUMAN (62-320): 8.18e-36: 140: 21.77
+	Hs
		338833 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LIGO1_HUMAN (61-232): 2.3e-16: 82.2: 17.73
+	Hs
		338643 EGFR_HUMAN (1-1210): 0: 1241: 100.00		LRRT4_HUMAN (64-201): 5.1e-13: 71.8: 21.43
+	Hs
		1070977 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		LRIG3_HUMAN (62-320): 8.18e-36: 140: 21.77
+	Hs
		383860 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		LRIG3_HUMAN (62-320): 8.18e-36: 140: 21.77
+	At
		1352201 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		Y1723_ARATH (31-359): 6.56e-46: 169: 18.49
+	At
		795001 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		Y1723_ARATH (31-359): 6.56e-46: 169: 18.49
+	At
		85102 F4I065_ARATH (417-1003): 2.31e-135: 436: 15.92		RGI2_ARATH (33-358): 7.87e-49: 178: 17.55
+	At
		95366 F4I065_ARATH (417-1003): 2.31e-135: 436: 15.92		RGI4_ARATH (25-359): 1.29e-45: 168: 18.91
+	At
		794999 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		IMK2_ARATH (141-358): 1.22e-30: 124: 15.99
+	At
		84503 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		GSO1_ARATH (2-211): 7.84e-25: 107: 17.94
+	At
		1341092 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		BAME2_ARATH (3-217): 1.05e-22: 101: 14.48
+	At
		84463 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		GSO1_ARATH (2-211): 7.84e-25: 107: 17.94
+	At
		221803 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		BAME1_ARATH (1-150): 1.68e-18: 89.1: 15.69
+	At
		83729 Y5182_ARATH (429-1004): 1.84e-136: 439: 14.89		CLV1_ARATH (2-196): 3.12e-27: 114: 15.96
+	At
		221760 TMK1_ARATH (345-984): 1.18e-139: 449: 15.52		BAME1_ARATH (1-150): 1.68e-18: 89.1: 15.69
+	At
		1338064 TMK3_ARATH (346-984): 2.89e-145: 464: 16.13		RGI1_ARATH (1-161): 6.84e-11: 65.6: 13.50
+	At
		83707 Y5182_ARATH (429-1004): 1.84e-136: 439: 14.89		BAME1_ARATH (1-150): 1.68e-18: 89.1: 15.69
+	At
		83704 Y5182_ARATH (429-1004): 1.84e-136: 439: 14.89		Y4361_ARATH (222-359): 5.21e-15: 78.3: 20.86
+	At
		84729 F4I065_ARATH (417-1003): 2.31e-135: 436: 15.92		Y4361_ARATH (222-359): 5.21e-15: 78.3: 20.86