HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SRPRA (P08240)
Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha)
Gene: SRPRA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	24797263, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0016020 - membrane
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 638
+	Hs
		438691 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		SRPRA_HUMAN (1-638): 0: 783: 100.00
+	Hs
		434117 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		SRPRA_HUMAN (1-638): 0: 783: 100.00
+	Hs
		411277 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		SRPRA_HUMAN (1-638): 0: 783: 100.00
+	Hs
		438676 INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90		SRPRA_HUMAN (1-638): 0: 783: 100.00
+	Hs
		435498 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		SRPRA_HUMAN (1-638): 0: 783: 100.00