HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: GNAI3 (P08754)
Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3)
Gene: GNAI3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	25187647, 19401591
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 354
+	Hs
		338256 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79
+	Hs
		338255 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GNAS2_HUMAN (1-353): 1.44e-139: 403: 38.68
+	Hs
		444699 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		GNAI3_HUMAN (1-354): 1.47e-176: 495: 100.00
+	Hs
		580464 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		GNAT2_HUMAN (1-354): 3.7e-167: 471: 69.49
+	Rn
		444646 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		GNAI3_RAT (1-354): 4.47e-175: 491: 98.59
+	Hs
		580414 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		GNAZ_HUMAN (1-353): 7.65e-156: 443: 67.23
+	Hs
		872647 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		GNA13_HUMAN (2-353): 2.06e-152: 435: 38.33
+	Hs
		670430 ZAP70_HUMAN (718-961): 5.57e-53: 199: 39.59		GNA11_HUMAN (1-353): 1.31e-156: 445: 50.28
+	Hs
		435603 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79