HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: THIO (P10599)
Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx)
Gene: TXN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	24658140, unassigned2173, 20029029, 15657067
Identification Methods	protein complementation assay, affinity chromatography technology, ubiquitin reconstruction, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0033138 - positive regulation of peptidyl-serine phosphorylation GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 105
+	Hs
		338707 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TXND5_HUMAN (12-105): 2.13e-27: 105: 27.00
+	Hs
		337778 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PDIA1_HUMAN (2-103): 7.44e-23: 92.9: 22.22
+	Hs
		495533 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		THIO_HUMAN (1-105): 6.33e-41: 132: 100.00
+	Hs
		383556 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		THIO_HUMAN (1-105): 6.33e-41: 132: 100.00
+	Hs
		495464 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		THIO_HUMAN (1-105): 6.33e-41: 132: 100.00
+	Hs
		383571 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85
+	Hs
		531718 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85
+	Hs
		434126 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85
+	Hs
		531732 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85
+	Hs
		411442 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		TXND5_HUMAN (12-105): 2.13e-27: 105: 27.00
+	Hs
		411285 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85
+	Hs
		411271 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		PDIA1_HUMAN (2-103): 7.44e-23: 92.9: 22.22
+	Rn
		102493 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		G3V6T7_RAT (3-104): 2.36e-23: 94.4: 25.69
+	Gg
		94428 KSYK_CHICK (718-961): 1.71e-55: 206: 41.30		THIO_CHICK (1-105): 3.19e-38: 125: 70.48
+	Hs
		537760 INSRR_HUMAN (352-656): 3.99e-25: 115: 20.90		TXND5_HUMAN (12-105): 2.13e-27: 105: 27.00
+	Hs
		435520 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		PDIA4_HUMAN (3-104): 4.21e-25: 99.4: 23.85
+	Hs
		423108 IGF1R_HUMAN (354-658): 1.12e-14: 81.4: 18.47		PDIA1_HUMAN (2-103): 7.44e-23: 92.9: 22.22