HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: MUC1 (P15941)
Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]
Gene: MUC1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.756

Property	Details
Experiments	25402006, 24658140, 11278868, 11483589, 16983337, 21258405, 17889671, unassigned2173
Identification Methods	two hybrid, protein complementation assay, affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation, ubiquitin reconstruction, cross-linking study, anti bait coimmunoprecipitation, coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005615 - extracellular space GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0016324 - apical plasma membrane GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 1255
+	Hs
		554307 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MUC1_HUMAN (1-1255): 1.21e-135: 448: 100.00
+	Hs
		383583 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		MUC1_HUMAN (1-1255): 1.21e-135: 448: 100.00
+	Hs
		554266 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MUC1_HUMAN (1-1255): 1.21e-135: 448: 100.00
+	Hs
		338149 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HCFC1_HUMAN (7-1107): 6.45e-29: 128: 11.01
+	Hs
		338965 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TARA_HUMAN (36-1064): 2.31e-23: 110: 8.69
+	Hs
		338878 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC4_HUMAN (296-1142): 2.14e-16: 87.5: 10.86
+	Hs
		338874 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MINT_HUMAN (22-1062): 3.99e-14: 80.1: 9.50
+	Hs
		338765 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MUC16_HUMAN (6-1154): 8.49e-11: 69: 9.53
+	Hs
		339147 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRRM2_HUMAN (105-1020): 1.64e-09: 64.9: 7.41
+	Hs
		1071005 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MUC4_HUMAN (296-1142): 2.14e-16: 87.5: 10.86
+	Hs
		383946 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		MUC4_HUMAN (296-1142): 2.14e-16: 87.5: 10.86
+	Hs
		601984 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MUC4_HUMAN (296-1142): 2.14e-16: 87.5: 10.86
+	Hs
		554283 ZAP70_HUMAN (718-961): 5.57e-53: 199: 39.59		MUC1_HUMAN (1-1255): 1.21e-135: 448: 100.00
+	Dm
		1001998 Q0KIF4_DROME (621-1017): 1.89e-113: 382: 32.07		Q9VLS7_DROME (4-946): 1.2e-18: 94.7: 11.85
+	Rn
		94371 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		F1M9G7_RAT (29-1028): 5.45e-21: 102: 12.12
+	Rn
		544878 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		SPEG_RAT (108-1155): 1.04e-14: 82.1: 10.96
+	Rn
		88946 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		D4A7D6_RAT (172-1250): 5.6e-12: 72.9: 8.43
+	Hs
		983695 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		SRRM2_HUMAN (105-1020): 1.64e-09: 64.9: 7.41
+	Hs
		166504 FAK1_HUMAN (716-991): 1.58e-53: 206: 37.68		NACAD_HUMAN (36-1074): 5.89e-09: 63: 13.06