HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: AT2A2 (P16615)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
Gene: ATP2A2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	24189400, 35384245, 23956138, 15657067
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0016020 - membrane GO:0019899 - enzyme binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 1042
+	Hs
		383590 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		AT2A2_HUMAN (1-1042): 0: 1060: 100.00
+	Hs
		383917 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		AT2A3_HUMAN (1-997): 0: 956: 76.85
+	Hs
		337753 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AT1A1_HUMAN (3-997): 0: 797: 26.72
+	Hs
		337946 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AT2B4_HUMAN (3-1028): 0: 762: 25.75
+	Hs
		383521 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		AT1A1_HUMAN (3-997): 0: 797: 26.72
+	Rn
		416146 INSR_RAT (579-1032): 2.5e-106: 367: 23.66		AT1A1_RAT (3-997): 0: 798: 26.82