HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.980

Property	Details
Experiments	7693694, 9050838, 10889023, 8621392, 25402006, 24658140, 9355745, 35384245, 15982634, unassigned2173
Identification Methods	pull down, affinity chromatography technology, x-ray crystallography, enzymatic study, two hybrid, protein complementation assay, proximity labelling technology, anti tag coimmunoprecipitation, ubiquitin reconstruction, anti bait coimmunoprecipitation and 1 others more... protein kinase assay
Interaction Type	direct interaction, physical association, association, phosphorylation reaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005737 - cytoplasm GO:0019899 - enzyme binding GO:0019901 - protein kinase binding GO:0032991 - protein-containing complex GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 435
+	Hs
		337897 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98
+	Hs
		337940 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39
+	Hs
		338349 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44
+	Mm
		728828 EGFR_MOUSE (1-1210): 0: 1258: 90.35		PTN12_MOUSE (24-314): 2.72e-120: 369: 32.68
+	Hs
		338312 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN12_HUMAN (24-314): 1e-122: 376: 33.55
+	Hs
		337941 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRD_HUMAN (1-278): 8.51e-109: 354: 31.45
+	Hs
		337831 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRF_HUMAN (19-278): 2.99e-105: 344: 30.94
+	Hs
		337909 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRA_HUMAN (12-278): 9.1e-105: 330: 31.62
+	Hs
		337942 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRE_HUMAN (3-278): 1.26e-92: 295: 26.71
+	Hs
		337802 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRC_HUMAN (16-337): 3.28e-77: 263: 22.95
+	Hs
		146919 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRT_HUMAN (6-278): 5.46e-63: 222: 26.57
+	Hs
		338458 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRK_HUMAN (6-279): 1.27e-61: 218: 25.18
+	Mm
		719299 EGFR_MOUSE (1-1210): 0: 1258: 90.35		PTN11_MOUSE (39-274): 4.54e-49: 177: 38.80
+	Hs
		339009 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRH_HUMAN (11-300): 1.33e-48: 180: 35.71
+	Hs
		338317 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		337943 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRG_HUMAN (342-435): 1.43e-21: 99.7: 13.46
+	Hs
		339171 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN22_HUMAN (297-430): 8.46e-19: 91.2: 13.10
+	Hs
		338901 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN18_HUMAN (342-434): 2.61e-17: 85.8: 12.87
+	Hs
		338787 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRU_HUMAN (341-434): 6.63e-17: 85.4: 13.59
+	Hs
		337987 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN6_HUMAN (342-432): 1.75e-12: 71.2: 10.48