HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PTPRA (P18433)
Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)
Gene: PTPRA

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.865

Property	Details
Experiments	28065597, 32062451, unassigned2173
Identification Methods	two hybrid, affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0016020 - membrane GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 802
+	Hs
		383597 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRA_HUMAN (1-802): 0: 1040: 100.00
+	Hs
		337941 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRD_HUMAN (38-799): 0: 897: 40.50
+	Hs
		337831 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRF_HUMAN (4-799): 0: 894: 40.52
+	Hs
		337942 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRE_HUMAN (130-802): 0: 836: 66.81
+	Hs
		337943 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRG_HUMAN (14-798): 0: 788: 29.12
+	Hs
		146919 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRT_HUMAN (51-795): 0: 778: 31.14
+	Hs
		338458 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRK_HUMAN (14-794): 0: 757: 32.41
+	Hs
		146927 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTPRT_HUMAN (51-795): 0: 778: 31.14
+	Hs
		146920 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRT_HUMAN (51-795): 0: 778: 31.14
+	Hs
		338349 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRJ_HUMAN (516-797): 1.76e-118: 390: 38.87
+	Hs
		337940 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRB_HUMAN (443-796): 5.85e-116: 389: 31.11
+	Hs
		337987 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTN6_HUMAN (504-796): 1.16e-112: 357: 32.47
+	Hs
		337802 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRC_HUMAN (211-516): 1.3e-77: 275: 28.91
+	Hs
		383611 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRB_HUMAN (443-796): 5.85e-116: 389: 31.11
+	Hs
		665895 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTN6_HUMAN (504-796): 1.16e-112: 357: 32.47
+	Hs
		338787 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRU_HUMAN (221-508): 2.18e-61: 227: 27.85
+	Hs
		339009 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PTPRH_HUMAN (529-792): 2.96e-52: 199: 38.58
+	Hs
		383545 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PTPRC_HUMAN (211-516): 1.3e-77: 275: 28.91
+	Rn
		1143998 ERBB4_RAT (7-1199): 0: 1138: 49.38		PTPRZ_RAT (126-516): 8.2e-53: 201: 22.91
+	Hs
		1071017 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		PTPRH_HUMAN (529-792): 2.96e-52: 199: 38.58