HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.978

The method score is based on:

Property Details
Experiments 11983899, 19605547, 9207933, 12803489, 25754235, 22973453, 12061819, 9756944, 16273093, 24797263, 14568990, 7693694, 7993895, 9020117
Identification Methods affinity chromatography technology, pull down, unspecified method, coimmunoprecipitation, cross-linking study, far western blotting, protein array
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0007173 - epidermal growth factor receptor signaling pathway
GO:0019901 - protein kinase binding
GO:0032587 - ruffle membrane
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024