HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: PPAC (P24666)
Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) (LMW-PTPase) (EC 3.1.3.48) (Adipocyte acid phosphatase) (Low molecular weight cytosolic acid phosphatase) (EC 3.1.3.2) (Red cell acid phosphatase 1)
Gene: ACP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24797263
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 158
+	Hs
		383617 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PPAC_HUMAN (1-158): 8.34e-88: 254: 100.00
+	Hs
		623729 EPHB1_HUMAN (640-1071): 8.83e-123: 405: 28.06		PPAC_HUMAN (1-158): 8.34e-88: 254: 100.00
+	Hs
		623719 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		PPAC_HUMAN (1-158): 8.34e-88: 254: 100.00
+	Hs
		623718 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		PPAC_HUMAN (1-158): 8.34e-88: 254: 100.00
+	Hs
		411300 INSR_HUMAN (451-1026): 9.86e-109: 374: 20.87		PPAC_HUMAN (1-158): 8.34e-88: 254: 100.00
+	Hs
		623725 ZAP70_HUMAN (718-961): 5.57e-53: 199: 39.59		PPAC_HUMAN (1-158): 8.34e-88: 254: 100.00
+	Gg
		94478 KSYK_CHICK (718-961): 1.71e-55: 206: 41.30		PPAC_CHICK (1-158): 1.7e-84: 246: 82.28
+	Mm
		796519 ZAP70_MOUSE (718-961): 2.03e-52: 197: 40.00		PPAC_MOUSE (1-158): 2.36e-84: 246: 86.08